spend, spent

07:15 Aug 11, 2012
This question was closed without grading. Reason: Other

English language (monolingual) [PRO]
Medical - Mathematics & Statistics / clinical trials
English term or phrase: spend, spent
All statistical type I error will be spent on the hypothesis tests performed on the data collected in the treatment period
[what does it mean in this context?]
kgas
Poland
Local time: 19:47


SUMMARY OF ALL EXPLANATIONS PROVIDED
5eliminated
B D Finch
3 +1use a spending function
DLyons
3 -1passed on
ErichEko ⟹⭐
Summary of reference entries provided
might help
Cristina Crişan

  

Answers


7 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): -1
spent
passed on


Explanation:

The errors of Type I will be passed on to the test, i.e. made as input for tjhe said test.

ErichEko ⟹⭐
Indonesia
Local time: 01:47
Native speaker of: Native in IndonesianIndonesian

Peer comments on this answer (and responses from the answerer)
disagree  B D Finch: Not possible! One cannot (and wouldn't want to) use errors of either Type 1 or Type 2 as input. Errors are not data!
1 hr
  -> Yeah, I see your point.
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1 hr   confidence: Answerer confidence 5/5
eliminated


Explanation:
It means that Type 1 errors (i.e. those leading to rejection of a true null hypothesis) will be eliminated by means of the tests in question.

B D Finch
France
Local time: 19:47
Native speaker of: English
PRO pts in category: 4

Peer comments on this answer (and responses from the answerer)
neutral  DLyons: "Reduce" perhaps, but "eliminate" is too strong.
1 hr
  -> Rationally, I agree with you. However, I think that "eliminated" is what the writer means.
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3 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +1
use a spending function


Explanation:
Probably arising in the context of deciding whether to stop the trial early.


    Reference: http://books.google.ie/books?id=KW9esgo759EC&pg=PA217&lpg=PA...
    Reference: http://www.niaid.nih.gov/about/organization/dcr/BRB/Document...
DLyons
Ireland
Local time: 18:47
Specializes in field
Native speaker of: English
PRO pts in category: 24

Peer comments on this answer (and responses from the answerer)
neutral  B D Finch: That does look possible.
3 days 3 hrs
  -> Thanks Barbara. It's not entirely clear from the extract but that's my best guess. I notice it's posted in Polish also and all three of us independently came up with the same suggestion.

agree  Doroteja
20 days
  -> Thanks Doroteja.
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Reference comments


5 hrs
Reference: might help

Reference information:
There are two ways of designing an O'Brien-Fleming design, a popular design for conducting interim analyses of clinical trials. The first method is to use an error (or alpha) spending function, which essentially gives you a "budget" of error you can spend at each interim analysis.
http://realizationsinbiostatistics.blogspot.ro/2007/09/my-ob...

Lan and DeMets developed a very flexible
boundary procedure that accommodates unequal
timing, additional looks, even extending the trial
– Called “alpha spending” functions
– Researchers can choose to “spend” their alpha (i.e.,
conduct interim analyses) any way they want
– Ensures that total alpha “spent” is no more than 0.05
(or whatever was specified)
http://www.icssc.org/Documents/AdvBiosGoa/Tab 25.00_InterimA...

Cristina Crişan
Romania
Native speaker of: Romanian
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