PBO-subtracted
English translation: after subtracting the results (or mean) for the placebo group from the total results (or mean)
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| 09:59 Feb 3, 2015 |
| English language (monolingual) [PRO] Science - Mathematics & Statistics / clinical trial | |||||||
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|  Selected response from: Charles Davis Spain Local time: 13:01 | ||||||
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| 4 | after subtracting the results for the placebo group from the total results |
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| 3 +1 | Treatment effect less PBO effect |
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| Discussion entries: 1 | |
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Answers
31 mins confidence: 
| pbo-subtracted after subtracting the results for the placebo group from the total results Explanation: PBO stands for placebo: "Treatment with ODN 50 mg once weekly for 2 years resulted in placebo (PBO)-subtracted mean increases..." http://press.endocrine.org/doi/abs/10.1210/endo-meetings.201... "Placebo-subtracted response Research The response in a treatment group minus the response in a control/placebo group." http://medical-dictionary.thefreedictionary.com/therapeutic ... So "PBO-subtracted difference" means the difference after excluding the placebo: the results corresponding to the group in the trial that received a placebo are subtracted, leaving just the results for the group that received the actual treatment. |
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7 hrs confidence: peer agreement (net): +1
peer agreement (net): +1| pbo-subtracted Treatment effect less PBO effect Explanation: Without seeing the data I can't be sure, but what I think is happening is that there's a pre-trial baseline followed by a trial with Lacosamide and a placebo, both of which show a difference from the baseline. So the trial is displaying a placebo effect and, to be conservative, this is subtracted from the observed LCM treatment effect. -------------------------------------------------- Note added at 7 hrs (2015-02-03 17:25:32 GMT) -------------------------------------------------- So it's a difference of two means, LCM mean (over people who had this treatment) - PBO mean (over people who received placebo). Reference: http://www.researchgate.net/profile/Jane_Meza/publication/23... |
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