Glossary entry

Spanish term or phrase:

medio

English translation:

moiety/group

    The asker opted for community grading. The question was closed on 2009-11-23 01:54:09 based on peer agreement (or, if there were too few peer comments, asker preference.)
Nov 19, 2009 10:20
14 yrs ago
6 viewers *
Spanish term

medio glicilamida adherido

Spanish to English Medical Medical: Pharmaceuticals
La drug name, una glicilciclina, inhibe la traducción de las proteínas en bacterias mediante la unión a la subunidad ribosómica 30S y el bloqueo del ingreso de las moléculas de amino-acil tRNA de transferencia al lugar A del ribosoma. Esto impide la incorporación de los residuos de aminoácidos en cadenas de péptidos en elongación. La drug name ***lleva un medio glicilamida adherido en la posición 9 de la minociclina***. El patrón de sustitución no está presente en ninguna drug semisintética o de ocurrencia natural y transmite determinadas propiedades microbiológicas a la drug name.

I would appreciate help with this sentence (between ***). This has been translated from English, so I am not sure if the term "medio" is used correctly.

Thank you

Proposed translations

+1
15 mins
Selected

glycyl amide moiety/group bound

The drug contains a glycyl amide moiety (group) bound to the 9 position of minocycline.
Peer comment(s):

agree slothm : Complete.
8 hrs
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4 KudoZ points awarded for this answer. Comment: "Thanks for giving the full sentence."
14 mins

glycyl amide moiety

glycyl amide moiety
En efecto, como sospechabas es una mala traducción de moiety, que literalmente significa "mitad", pero que en este contexto significa fracción, parte o grupo de una molécula.

nhibition of Trypanothione Reductase by Substrate Analogues ...
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One possibility would be to replace the offending ***glycyl amide moieties *** with less nucleophilic esters (i.e. replace the glycyl residues with glycolates). ...
pubs.acs.org/doi/abs/10.1021/ol0065423

Bioorganic & Medicinal Chemistry Letters : Nonpeptide αvβ3 ...
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... suggests that the N-terminal moiety can play a critical role in ... Constraining the glycyl amide of Scheme 1 and 1 through cyclization into the ...
linkinghub.elsevier.com/retrieve/pii/S0960894X01006874
Note from asker:
Gracias, Andrés por la aclaración. Saludos desde Buenos Aires.
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