Glossary entry

Spanish term or phrase:

pTie NO

English translation:

PT1c ( Tumor >10 mm but 20 mm in greatest dimension) with no regional lymph node metastasis

Added to glossary by liz askew
Nov 24, 2009 08:29
14 yrs ago
10 viewers *
Spanish term

pTie NO

Spanish to English Medical Medical (general) Breast Cancer
This abbreviation shows up in a report about a patient with breast cancer.

The sentence describes the patient's diagnosis: "Diagnosticada en [fecha] de Carcinoma Ductal Infiltrante de mama izquierda pTie NO, RH +."

I think that these are the letters; it's a bad copy but I believe I'm reading this correctly!

What is this saying, please, and how can I say it in English?
Change log

Nov 26, 2009 20:06: liz askew changed "Edited KOG entry" from "<a href="/profile/578038">Joseph Tein's</a> old entry - "pTie NO"" to ""PT1c ( Tumor >10 mm but 20 mm in greatest dimension) with no regional lymph node metastases""

Discussion

Barbara Thomas Nov 26, 2009:
TNM staging isn't translated It's important to know what the code stands for, but you don't actually "translate" the TNM stage. Wikipedia is a good source for explanations (http://en.wikipedia.org/wiki/TNM_staging_system)
Joseph Tein (asker) Nov 24, 2009:
pT1c My final correction: I find a lot of Google references for "pT1e" and "pT1c" ... I think these are different types of cancer descriptions. Any explanation would still be helpful!
Joseph Tein (asker) Nov 24, 2009:
pTIc Actually, I didn't read it correctly. I'm finding this "pTIc" abbreviation in the context of cancer and am trying to research it further. Any help and suggestions are still very welcome!

Proposed translations

1 hr
Selected

PT1c ( Tumor >10 mm but 20 mm in greatest dimension) with no regional lymph node metastases

Hope I have got this right as this is soooo important.

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Note added at 1 hr (2009-11-24 09:34:30 GMT)
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hi
perhaps the last bit should read


no evidence of regional lymph node...

??

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Note added at 1 hr (2009-11-24 09:35:25 GMT)
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HER2
- [ Translate this page ]
pT1c pNO MO.ca de mama restante RTprevia, sin RT axilar. ... Si los RH son positivos cuando se produce una recaída exclusivamente ósea habitualmente no se ...
www.her2.roche.es/mc_nuevo/consultas_mama.php - Cached - Similar

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Note added at 1 hr (2009-11-24 09:45:34 GMT)
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p.s.

RH = receptores hormonales

???

Revista Salud Uninorte - Analysis of the immunohistopathological ...
- [ Translate this page ]
The infiltrating ductal carcinoma grades II and III were the histological ... 88.03 % of the cases were positive for estrogens and progestagens. ... Los receptores hormonales (RH) son los menos polémicos, y los tumores positivos para ..... Ten years follow-up results of patients with carcinoma of the breast in a ...
www.scielo.org.co/scielo.php?pid=S0120...script=sci... - Cached - Similar
by LAS Arenas - 2007 - Related articles

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Note added at 1 hr (2009-11-24 09:47:44 GMT)
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it would seem so.

http://209.85.229.132/search?q=cache:ygcR-sQ9XsgJ:dialnet.un...


Como mecanismo de control interno, y con el fin de predecir la tasa esperable de ganglios centinela en nuestra
población, hemos analizado la tasa de invasión axilar en los últimos 400 casos de cáncer de mama pT1 operados
por nosotros utilizando la técnica clásica de linfadenectomía axilar completa.
De los 400 tumores 336 (84.0%) fueron carcinomas ductales infiltrantes NOS, 32 (8.0%) carcinomas lobulillares, 22
carcinomas tubulares puros (5.5%), y los 10 restantes correspondieron a otras variedades histológicas menos
frecuentes.
La distribución por tamaños fue la siguiente: 0-5 mm (pT1a), 13 casos; 6-10 mm (pT1b), 102 casos; 11-20 mm (pT1c),
285 casos.
Mediante el test de Spearman, correlacionamos la presencia de metástasis ganglionares de la axila con todos los
datos clínicos y biológicos disponibles (histología, tamaño, grado histológico y nuclear, receptores hormonales,
Ki67, c-erb-B2 y p53).
Ninguno de los 13 casos de tumor pT1a presentó invasión ganglionar, frente a 19 casos de los 102 pT1b (18.6%) y
93 de los pT1c (32.6%


Saludos!

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Note added at 1 hr (2009-11-24 10:09:52 GMT)
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Well, as for the "NO", you will have to follow this up yourself...I don't have time.

Estadio, grado y pronóstico de un tumor | elmundosalud.es
- [ Translate this page ]
A mi esposa la diagnosticaron un cáncer en la mama derecha (T1N0M0). Diagnóstico patológico: pT1c pN0 (7 ganglios axilares negativos) M0. ...
www.elmundo.es › Salud › Cáncer › Dudas y preguntas - Cached - Similar

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Note added at 1 hr (2009-11-24 10:12:16 GMT)
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Look here too:

http://209.85.229.132/search?q=cache:hR7ENfM9ogEJ:www.marian...

Can I just say that this is not a guessing game, so you need to be 100% clear what your source text says, and if you are not sure then go back to the client and get a 100% clear copy! :)

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Note added at 5 hrs (2009-11-24 14:12:02 GMT)
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Breast Cancer Research | Full text | Comparison of written reports ...
The majority of invasive breast cancers were staged as pT1c (44%). ... By all three techniques, one invasive ductal carcinoma (pT1b) was misinterpreted as fibroadenoma. .... Ciatto S, Rosselli del Turco M, Catarzi S, Morrone D: The contribution ... Felber S: Dignity evaluation of focal mamma lesions: a prospective ...
breast-cancer-research.com/content/3/1/55 - Cached - Similar
by S Malur - 2000 - Cited by 66 - Related articles - All 10 versions


I would advise you to post "NO" as a separate query

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Note added at 5 hrs (2009-11-24 14:13:15 GMT)
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Hey
I have just found this:

El diagnóstico es CARCINOMA DUCTAL INFILTRANTE ESTADÍO I (pT1c, N0) (querría que me explicaran un poquito más esto), y entre las indicaciones que se dan a continuación, explica que presenta escasa respuesta linfocitaria...qué significado tiene ésto?
grado histológico II (2+3+1) (esto no lo entiendo)

Still looking...

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Note added at 5 hrs (2009-11-24 14:14:51 GMT)
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and here is the answer

http://209.85.229.132/search?q=cache:j3A8NzLzC2kJ:www.fefoc....


Distinguida amiga: Ante todo, gracias por tenernos como referencia. Muchas de las preguntas que se hace, muy lógicas, están bien respondidas en nuestra página específica para cáncer de mama (www.cancermama.org). Allí encontrará una amplia información, en forma de preguntas y respuestas, sobre todas las cuestiones relativas a este cáncer. Pero no tenemos inconveniente en responder aquí a sus preguntas, por si le facilitamos la información: 1. Carcinoma ductal infiltrante: es el tumor que se forma en un conducto de la mama y lo rebasa, se exterioriza, infiltra el tejido vecino. Es el más frecuente (80%) de todos los cánceres de mama. 2. Estadio I: se trata de tumores de menos de dos centímetros de diámetro mayor y sin ganglios afectados en la axila. Excelente pronóstico: 90% de pacientes con supervivencia sin enfermedad. 3. Grado II/III. Grado es la relación entre el tejido mamario que se contempla al microscopio y el número de células tumorales que están en mitosis. Expresa en cierta manera la actividad del tumor. En su caso es media (II) a alta (III). pero los factores pronósticos más importantes favorables son tamaño del tumor, no ganglios axilares y receptores hormonales positivos. 4. K1 67: expresa la agersividad del tumor, pero vale lo dicho para el grado sobre factores pronósticos. 5. HER-2 positivo (+) una cruz. Las pacientes positivas tres cruces (+++) precisan un tratamiento especial porque expresan un oncogen de gran agresividad. No es, afortunadamente, el caso de la paciente. En resumen, la paciente, según los datos que usted aporta, tiene un excelente pronóstico. Recomiéndele que siga la dieta mediterránea, que haga ejercicio físico diario 8según la medida de sus posibilidades y si carece de otras enfermedades) y que no lleve pesos con la extremidad del lado intervenido. Quedamos a su disposición para cuanta información podamos proporcionarles. Afectuosa y atentamente, FEFOC


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Note added at 5 hrs (2009-11-24 14:18:41 GMT)
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PREGUNTA.- Paciente de 42 años, sin hijos, intervenida en noviembre de 2006 de un carcinoma de mama, procediéndose a cuadrantectomía con biopsia selectiva de ganglio centinela. Los márgenes estaban limpios. Diagnóstico definitivo: carcinoma ductal infiltrante G-II de 1,6 cms sin afectación axilar. Estadio Pt1c N0 M0. RE (+) RP (+). C-erb-2 (-). Mi oncóloga me informó de que el pronóstico era bueno.

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Note added at 5 hrs (2009-11-24 14:22:20 GMT)
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look

Surgery of the breast: principles and art - Google Books Result
by Scott L. Spear - 2006 - Medical - 1517 pages
There is usually an underlying extensive ductal carcinoma in situ (DCIS). ... NO, MO T1, NO, MO TO, N1, MO T1 N1, MO T2, NO, MO TO, N2, MO T1 N2, MO T2, N2, ...
books.google.co.uk/books?isbn=0781747562...

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Note added at 5 hrs (2009-11-24 14:23:09 GMT)
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NO

=
no regional lymph node metastases



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Note added at 5 hrs (2009-11-24 14:23:40 GMT)
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sorry
metastasis

so I was right all along:)

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Note added at 5 hrs (2009-11-24 14:25:54 GMT)
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BTW

NO = no regional lymph node metastasis
pNO = no regional lymph node metastasis histologically

so, yes, a wee difference here.



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Note added at 5 hrs (2009-11-24 14:26:10 GMT)
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send me the cheque in the post:)

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Note added at 2 days11 hrs (2009-11-26 20:09:37 GMT) Post-grading
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Thank you for your additional comments Joseph. Without going into the detail, my mum died of terminal cancer (breast) so this subject is close to my heart. At the time I did not know much about the subject, but every time I read up on it I realise just what a horrible disease this can be, particularly if not caught early.
Note from asker:
Thanks Liz. This was completely mystifying and now it's clearer. I still can't really read whether it says pT1c or 'e' on my copy, but from the descriptions in your reference it looks like it would have to be a 'c'.
In response to your comment above -- 'this is sooo important' -- this translation is related to a clinical trial investigation where the research organization is studying any possible adverse effects related to the latest drug they're trying to market. I trust that the patient -- the human being involved here -- received the appropriate care at the time of her hospital admission. I absolutely agree that we need to be 100% correct when translating/interpreting something that could impact a person's health or medical treatment!
Something went wrong...
4 KudoZ points awarded for this answer. Comment: "Buenos días Liz. Thank you very much for your help with this, and for all the work and time you put into it."
4 hrs

No intraepithelial penetration (involvement)

You can use the abbreviation as it stands as it is universal
The PT stands for Tumour Pathology (category) and I suppose the "ie" is for "intraepithelial"


intraepithelial carcinoma (pTie)
pTis be divided into two categories: pTie: intraepi thelial and pTim: intramucosal. .... with intraepithelial carcinoma by others.
If you have time read this article
http://www.cap.org/apps/docs/pathology_reporting/Prognostic_...


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Note added at 4 hrs (2009-11-24 12:36:28 GMT)
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Of course if it is a "c" Liz is probably correct
Peer comment(s):

neutral liz askew : But Joseph has stated it is "pT1c"...not "pTie". As I said he should get back to the client for 100% clarification.
1 hr
Something went wrong...

Reference comments

1 hr
Reference:

Take a look here for "pT1c" - it is about tumo/u/r dimension

[PDF]
Cancerologia revista 2000427:Maquetación 1.qxd
- [ Translate this page ]
File Format: PDF/Adobe Acrobat - View as HTML
Carcinoma ductal infiltrante de mama izquierda .... 19% pT1b (6,1-10 mm) y del 30% en los pT1c (10,1- 20 mm).11-14. De los 339 pT1a analizados por el ...
www.socargcancer.org.ar/rcs/nmr/Cancerologiarevista2000427....
by AM ARGENTINA - Related articles - All 27 versions

http://arpa.allenpress.com/arpaonline/?request=get-document&...


pT1: Tumor 20 mm in greatest dimension

__pT1mic: Tumor 1 mm in greatest dimension (microinvasion)

__pT1a: Tumor >1 mm but 5 mm in greatest dimension

__pT1b: Tumor >5 mm but 10 mm in greatest dimension

__pT1c: Tumor >10 mm but 20 mm in greatest dimension

__pT2: Tumor >20 mm but 50 mm in greatest dimension


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Note added at 1 hr (2009-11-24 09:31:20 GMT)
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Also, I believe it should read "pNO" =

#
Breast Cancer Search Results
Dimension pT1c tumor more than 1.0 cm but not more than 2.0 cm in greatest dimension pN0 no regional lymp node. metastasis . ...
www.healthcentral.com › Breast Cancer Home › Find - Cached - Similar
# [DOC]
Explanatory Notes for Oral Cancer Checklist
File Format: Microsoft Word - View as HTML
pT1mic: Microinvasion 0.1 cm or less in greatest dimension ... pT1c: Tumor more than 1.0 cm but not more than 2.0 cm in greatest dimension ... pN0: No regional lymph node metastasis histologically (ie, none greater than 0.2 mm), ...
www.twiap.org.tw/.../Explanatory note for breast cancer[3]-...

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Note added at 1 hr (2009-11-24 09:32:23 GMT)
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[PDF]
VALOR DEL ANTIGENO CARCINOEMBRIONARIO EN CANCER DE LA MAMA
- [ Translate this page ]
File Format: PDF/Adobe Acrobat - View as HTML
principio de ectasia ductal, enfermedad crónica qulstica comunicante o un papiloma intraductal. ..... pTis Carcinoma pre-invasivo (carcinoma in—situ) ... pNO No hay evidencia de invasion a ganglios regionales ...
www.tesis.ufm.edu.gt/pdf/956.pdf
Note from asker:
... although the text clearly -- no mistakes due to blurring -- says "pT1c NO, ... etc." There isn't a 'pNO'.
Something went wrong...
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