This question was closed without grading. Reason: Answer found elsewhere
Apr 4, 2014 13:24
10 yrs ago
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Spanish term
Netherlands
Broad medical experience
Native in: English (Variants: US, UK) 
Works in: Spanish to English, Portuguese to English
90% de tres horas del platino plasmático
Spanish to English
Medical
Medical (general)
Cancer drugs: cisplatin
From a professional information sheet on Cisplatin:
Se une a las proteínas tres horas después de una inyección de bolo intravenoso y dos horas después del final de una infusión al 90% de tres horas del platino plasmático.
I get really lost at the end of this one...any thoughts?
Gracias,
Juliette
Se une a las proteínas tres horas después de una inyección de bolo intravenoso y dos horas después del final de una infusión al 90% de tres horas del platino plasmático.
I get really lost at the end of this one...any thoughts?
Gracias,
Juliette
Proposed translations
(English)
| 3 | reached 90% after 3 hours of plasma platinum |
DLyons
|
Proposed translations
2 hrs
reached 90% after 3 hours of plasma platinum
3 hours of an intravenous injection. Plasma platinum concentration would usually be in μg/ml, so this may be 90% of its final peak value.
Reference comments
17 mins
Reference:
see
http://alldrugs.info/cisplatin
Protein Binding:
Cisplatin does not undergo instantaneous and reversible binding to plasma protein that is characteristic of normal drug-protein binding. However, the platinum itself is capable of binding to plasma proteins, including albumin, transferrin, and gamma globulin. Three hours after a bolus injection and two hours after the end of a three-hour infusion, 90% of the plasma platinum is protein bound.
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Note added at 31 mins (2014-04-04 13:55:51 GMT)
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your source text is very mixed up!
Protein Binding:
Cisplatin does not undergo instantaneous and reversible binding to plasma protein that is characteristic of normal drug-protein binding. However, the platinum itself is capable of binding to plasma proteins, including albumin, transferrin, and gamma globulin. Three hours after a bolus injection and two hours after the end of a three-hour infusion, 90% of the plasma platinum is protein bound.
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Note added at 31 mins (2014-04-04 13:55:51 GMT)
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your source text is very mixed up!
Peer comments on this reference comment:
| agree |
Andrés Martínez
: Coincidimos. Un saludo.
1 hr
|
|
Gracias!
|
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| agree |
Neil Ashby
: I agree, looks like an infusion that lasts for 3 hours.
1 day 19 hrs
|
Discussion
Taken from the http://www.drugs.com/pro/cisplatin.html
Three hours after a bolus injection and two hours after the end of a three-hour infusion, 90% of the plasma platinum is protein bound.