English to Spanish Medical Medical: Pharmaceuticals

Estoy traduciendo un estudio titulado "Early and Late Benefits of Prasugrel in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention A TRITON–TIMI 38 (TRial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet InhibitioN with Prasugrel–Thrombolysis In Myocardial Infarction) Analysis".

"**Landmark analyses** were performed with the pre-specified windows of randomization to day 3 and from day 3 to the end of the trial. The landmark method of survival analysis uses a fixed time after the initiation of treatment to assess the response in treatment groups. **Landmark analysis** specifies the cutpoint in time after start of treatment without regard to patient response to therapy. Of importance, this specification provides us the opportunity to perform a separate statistical test to determine whether the response to treatment after the landmark time is different in the treatment groups. It should be noted that a limitation of **landmark analysis** is that the original effects of randomization at entry into the trial are no longer present because of deaths or dropouts before the time of the landmark cutpoint. There is a precedent for **landmark analyses** in both oncology and cardiology, but because of the observational nature of landmark methodology, the findings should be interpreted in the context of cumulative survival analyses from randomization to the end of the study (as reported previously for TRITON–TIMI 38).
The rationale for selection of the day 3 cutpoint for the **landmark analyses** was to separate, as much as possible, events that could be attributed to the loading dose (periprocedural events) and maintenance dose (events during long-term follow-up) phases of the study. "

En el Glosario de ensayos clínicos de Saladrigas y colaboradores, he encontrado que "landmark study" = estudio de referencia (Estudio clínico de gran tamaño que busca zanjar definitivamente una cuestión diagnóstica o terapéutica en medicina.)

Por otra parte, en el libro rojo de Navarro dice:
"landmark. Tiene tres significados frecuentes:
1 hito (histórico). ◘ The discovery of penicillin in 1928 was a landmark in the history of infectious diseases (el descubrimiento de la penicilina en 1928 constituyó un hito en la historia de las enfermedades infecciosas).
2 punto de referencia. ● anatomical landmark (punto anatómico de referencia), → landmark study (estudio de referencia).
3 monumento, edificio distintivo o lugar emblemático (de una ciudad o de un territorio). ◘ The Eiffel Tower is the most famous landmark of Paris (la torre Eiffel es el monumento más conocido [o emblemático] de París)."

¿A qué se refieren los "landmark analyses" y cómo se traduce la expresión?

Mil gracias por adelantado