Glossary entry (derived from question below)
English term or phrase:
tree gatekeeping procedure
Dutch translation:
poortwachtersprocedure met boomstructuur
Added to glossary by
Katrien De Clercq
Jan 30, 2015 10:58
9 yrs ago
2 viewers *
English term
tree gatekeeping procedure
English to Dutch
Other
Mathematics & Statistics
Klinische onderzoeken
"The Bonferonni statistic is part of a tree gatekeeping procedure used to maintain strong control of the type I error rate in testing hypotheses among the primary and secondary efficacy endpoints."
Ik heb geen enkel idee hoe ik "tree gatekeeping procedure" moet vertalen. Heb het ook nog nooit aangetroffen in deze context. Kan iemand me hierbij helpen?
Ik heb geen enkel idee hoe ik "tree gatekeeping procedure" moet vertalen. Heb het ook nog nooit aangetroffen in deze context. Kan iemand me hierbij helpen?
Proposed translations
(Dutch)
2 +1 | "gatekeeper"/"poortwachter" procedure | DLyons |
Proposed translations
+1
1 hr
Selected
"gatekeeper"/"poortwachter" procedure
I think it needs an explanatory note. I'd be inclined to keep the English word "gatekeeper" (in quotes) - professionals will understand it. "poortwachter" may be misleading as it's so much associated with clinical practice.
You could maybe literally translate "a Dmitrienko-style gatekeeping procedure"?
You could maybe literally translate "a Dmitrienko-style gatekeeping procedure"?
Peer comment(s):
agree |
Barend van Zadelhoff
: no references / I can't find 'gatekeeper' nor 'poortwachter' in Dutch literature in this field. // Ik stel voor: 'boomgestructureerde gatekeepingprocedure'
11 hrs
|
Thanks Barend. There certainly aren't any online and there may be none at all. That's why I'm recommending quotes and/or English.
|
2 KudoZ points awarded for this answer.
Comment: "I did indeed keep de 'poortwachter' structure. Thank you!"
Reference comments
4 hrs
Reference:
tree gatekeeping
Hierin wordt het allemaal uitgelegd.
A Mixture Gatekeeping Procedure Based on the
Hommel Test for Clinical Trial Applications
http://www.multxpert.com/doc/bxdt2011.pdf
A Mixture Gatekeeping Procedure Based on the
Hommel Test for Clinical Trial Applications
http://www.multxpert.com/doc/bxdt2011.pdf
Peer comments on this reference comment:
agree |
DLyons
: Yes, Hommel has extensions to Dmitienko's original procedure. They may or may not apply in this case. Using just "Dmitrienko-style" is safe.
16 hrs
|
1 day 6 hrs
Reference:
gatekeeping procedure
3 soorten gatekeeping procedures
- parallel
- serial
- tree-structured
tree-structured is een uitbreiding op 'parallel' en 'serial':
Tree gatekeeping procedures
Efficient way to account for hierarchically ordered multiple objectives in clinical trials.
Extend serial and parallel gatekeeping methods
http://www.bassconference.org/PDFs/BASS 2006 Dmitrienko et a...
It is becoming increasingly common to consider designs with multiple endpoints, analyses and objectives in registration studies because additional information on the efficacy and safety profiles of an experimental drug helps patients, prescribing physicians and payers better understand its properties. More complicated study designs give rise to more sophisticated analysis methods. In the area of multiple comparisons, these problems motivated research on novel testing strategies for hierarchically ordered objectives.
This paper gives an overview of recent developments in this area with emphasis on testing strategies for multiple families of analyses.
The analyses are often related to multiple endpoints (both primary and secondary) but can also represent dose–control comparisons, noninferiority and superiority tests or inferences at several time points. Testing strategies considered here are commonly referred to as gatekeeping strategies. This terminology highlights the fact that the families of analyses are examined sequentially and each one serves as a gatekeeper for the subsequent families. The sequential testing approach reflects the hierarchical nature of the problem and improves the power of the more important analyses placed early in the sequence.
The paper is organized as follows. Section 2 introduces the basic concepts about gatekeeping and establishes notation. Section 3 describes serial gatekeeping procedures and Section 4 describes parallel gatekeeping procedures. A generalization of the two approaches, termed the tree gatekeeping approach, is considered in Section 5.
Tree gatekeeping procedures enable clinical trial researchers to construct testing strategies that combine serial and parallel gatekeepers and also account for logical restrictions among multiple analyses conducted in a clinical trial.
http://users.iems.northwestern.edu/~ajit/papers/40) Gatekeep...
'gatekeeping procedures' zijn gerelateerd aan het 'multiple comparions problem' (zie boven; in het Nederlands 'kanskapitalisatie') --> :
In statistics, the multiple comparisons, multiplicity or multiple testing problem occurs when one considers a set of statistical inferences simultaneously or infers a subset of parameters selected based on the observed values
http://en.wikipedia.org/wiki/Multiple_comparisons_problem
In Dutch: kanskapitalisatie
http://nl.wikipedia.org/wiki/Kanskapitalisatie
Er zijn vele correctiemethoden voor kanskapitalisatie. Een bekende methode is de Bonferroni-correctie.
http://nl.wikipedia.org/wiki/Kanskapitalisatie
De Bonferroni-correctie (of Bonferroni-procedure) is een statistische methode ter bestrijding van het probleem van kanskapitalisatie.
http://nl.wikipedia.org/wiki/Bonferroni-correctie
Wanneer moet ik corrigeren voor multiple testing?
http://os1.amc.nl/wikistatistiek/index.php?title=Multiple_te...
gatekeeping procedure
http://www.proz.com/kudoz/english_to_dutch/medical_general/4...
- parallel
- serial
- tree-structured
tree-structured is een uitbreiding op 'parallel' en 'serial':
Tree gatekeeping procedures
Efficient way to account for hierarchically ordered multiple objectives in clinical trials.
Extend serial and parallel gatekeeping methods
http://www.bassconference.org/PDFs/BASS 2006 Dmitrienko et a...
It is becoming increasingly common to consider designs with multiple endpoints, analyses and objectives in registration studies because additional information on the efficacy and safety profiles of an experimental drug helps patients, prescribing physicians and payers better understand its properties. More complicated study designs give rise to more sophisticated analysis methods. In the area of multiple comparisons, these problems motivated research on novel testing strategies for hierarchically ordered objectives.
This paper gives an overview of recent developments in this area with emphasis on testing strategies for multiple families of analyses.
The analyses are often related to multiple endpoints (both primary and secondary) but can also represent dose–control comparisons, noninferiority and superiority tests or inferences at several time points. Testing strategies considered here are commonly referred to as gatekeeping strategies. This terminology highlights the fact that the families of analyses are examined sequentially and each one serves as a gatekeeper for the subsequent families. The sequential testing approach reflects the hierarchical nature of the problem and improves the power of the more important analyses placed early in the sequence.
The paper is organized as follows. Section 2 introduces the basic concepts about gatekeeping and establishes notation. Section 3 describes serial gatekeeping procedures and Section 4 describes parallel gatekeeping procedures. A generalization of the two approaches, termed the tree gatekeeping approach, is considered in Section 5.
Tree gatekeeping procedures enable clinical trial researchers to construct testing strategies that combine serial and parallel gatekeepers and also account for logical restrictions among multiple analyses conducted in a clinical trial.
http://users.iems.northwestern.edu/~ajit/papers/40) Gatekeep...
'gatekeeping procedures' zijn gerelateerd aan het 'multiple comparions problem' (zie boven; in het Nederlands 'kanskapitalisatie') --> :
In statistics, the multiple comparisons, multiplicity or multiple testing problem occurs when one considers a set of statistical inferences simultaneously or infers a subset of parameters selected based on the observed values
http://en.wikipedia.org/wiki/Multiple_comparisons_problem
In Dutch: kanskapitalisatie
http://nl.wikipedia.org/wiki/Kanskapitalisatie
Er zijn vele correctiemethoden voor kanskapitalisatie. Een bekende methode is de Bonferroni-correctie.
http://nl.wikipedia.org/wiki/Kanskapitalisatie
De Bonferroni-correctie (of Bonferroni-procedure) is een statistische methode ter bestrijding van het probleem van kanskapitalisatie.
http://nl.wikipedia.org/wiki/Bonferroni-correctie
Wanneer moet ik corrigeren voor multiple testing?
http://os1.amc.nl/wikistatistiek/index.php?title=Multiple_te...
gatekeeping procedure
http://www.proz.com/kudoz/english_to_dutch/medical_general/4...
Discussion
...boomgestructureerde gatekeepingprocedure
http://www.proz.com/kudoz/english_to_dutch/medical_general/4...
Look at what Jan Willem van Dormolen says.
**Signifikansnivå = final dubbelsidig signifikansnivå (alfa) för testet efter utökad gatekeepingprocedure.
OK, it's Swedish but I think it's the same issue as in Dutch.
Ik stel dan het volgende voor:
The Bonferonni statistic is part of a tree gatekeeping procedure...
De Bonferroni-correctie maakt deel uit van een boomgestructureerde gatekeepingprocedure...
P.S. It's Bonferroni.