thermo explorer

English to French Science Chemistry; Chem Sci/Eng In a patent: chemistry, chromatography

Step 1. Halide monomers (300 mmol) were dissolved anhydrous DMF (10 ml/mmol, 3 ml) under argon atmosphere.
NaH (60% suspension in mineral oil, 2 equiv, 600 mmol, 􀁡30 mg) was added at 0 °C to each reaction vial. Each
reaction vial was stirred at 0 °C for 30 min. SEM chloride (2 equiv, 600 mmol, 106 mL) was added dropwise to the reaction
mixture and stirring was continued at 25 °C for 16 hrs. Completion of reaction was monitored by LCMS/TLC and solvents
were stripped off using thermo explorer (1 hr, 5 torr, (0.66 kPa) and 45 °C). The residue was purified by column chromatography
using 5-10% ethyl acetate-hexane as eluent. For each monomer yield was around 75-80%.

The reaction was checked by LCMS. The reaction mixture was filtered and the solvent was evaporated
in thermo explorer (1 hr, 5 torr, and 45°C)