chased with

anglais vers français Droit / Brevets Brevets chemistry, chromatography

LC-MS showed most of tert-butyl 4-((7-(tert-butylcarbamoyl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)oxy)piperidine-1-carboxylate was consumed. The resulting mixture was concentrated in vacuo, and chased with DCM several times to give the crude TFA salt of N-(tert-butyl)-5-(hydroxymethyl)-2-(piperidin-4-yloxy)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (200 mg, 􀁡0.29 mmol) as oil which was used to next step
without further workup.

The resulting mixture was evaporated in vacuo, and chased with DCM several times to give a crude N-(tert-butyl)-2-(piperidin-4-yloxy)-5Hpyrrolo[
2,3-b]pyrazine-7-carboxamide (160 mg, 0.29 mmol) as an oil which was used to next step without further workup.