Oct 29, 2021 20:46
2 yrs ago
21 viewers *
Czech term
United Kingdom
A REAL English native speaker!
Native in: English 
Works in: Czech to English, Slovak to English
útočná dávka
Czech to English
Medical
Medical: Pharmaceuticals
U těžkých stavů vyžadujících *útočnou dávku* se podávají 2-3 mg/kg tělesné hmotnosti/den rozděleně do 3-4 dávek.
Any ideas? I've never heard this before. The medicine concerned is prednisone
Thanks
Any ideas? I've never heard this before. The medicine concerned is prednisone
Thanks
Proposed translations
(English)
| 4 +1 | initial dose/loading dose |
Anna Zahorska
|
| 4 +1 | high dose |
Anton Konashenok
|
| 2 | burst (dose) |
Andrzej Ziomek
|
Proposed translations
+1
1 hr
Anna Zahorska
United Kingdom
United Kingdom
Native in Czech
Specializes in field
United Kingdom
Related KudoZ points
:
4
Selected
initial dose/loading dose
The first or first two doses that are stronger and in shorter time interval than the maintenance dose that follows.
Peer comment(s):
| agree |
Emil Kucera
: Loading would be my choice. Lots of examples on the web
16 hrs
|
|
Děkuji.
|
4 KudoZ points awarded for this answer.
Comment: "thanks!"
+1
2 hrs
Anton Konashenok
Czech Republic
Czech Republic
Native in English
Specializes in field
Czech Republic
Competing on quality, not on price
Native in: Russian 
, English
Works in: French to English, Czech to English, Danish to English, and 10 more.
high dose
Or even "exceptionally high dose". The literal translation, "shock dose", was used in medical literature many decades ago but not anymore.
Anna's variant, loading/initial dose, is one of the cases when a high dose is administered, but it does not match your context. Here, it's just a high dose warranted by the severity of the condition. For prednisone, the most typical condition requiring an exceptionally high dose is a circulatory shock, or possibly a situation when the patient in a critical condition needs to be transported for much longer than usual (e.g. rough terrain and no helicopter). Similarly, patients in prolonged severe pain (cancer, extensive burns, etc.) may require (and will easily tolerate) a dose of opiates that is otherwise considered lethal.
Source: my own past experience as a mountain rescue paramedic.
Anna's variant, loading/initial dose, is one of the cases when a high dose is administered, but it does not match your context. Here, it's just a high dose warranted by the severity of the condition. For prednisone, the most typical condition requiring an exceptionally high dose is a circulatory shock, or possibly a situation when the patient in a critical condition needs to be transported for much longer than usual (e.g. rough terrain and no helicopter). Similarly, patients in prolonged severe pain (cancer, extensive burns, etc.) may require (and will easily tolerate) a dose of opiates that is otherwise considered lethal.
Source: my own past experience as a mountain rescue paramedic.
Peer comment(s):
| agree |
Hannah Geiger (X)
16 hrs
|
|
Děkuji!
|
3 days 19 hrs
Andrzej Ziomek
Poland
Poland
Poland
Jack of all trades Master of translation
Native in: Polish
Works in: English to Polish, Polish to English
burst (dose)
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Note added at 3 days 19 hrs (2021-11-02 16:04:06 GMT)
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https://jamanetwork.com/journals/jamapediatrics/fullarticle/...
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Note added at 3 days 19 hrs (2021-11-02 16:06:12 GMT)
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https://www.uptodate.com/contents/prednisone-drug-informatio...
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Note added at 3 days 19 hrs (2021-11-02 16:11:25 GMT)
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https://pubmed.ncbi.nlm.nih.gov/8388401/
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Note added at 3 days 19 hrs (2021-11-02 16:15:57 GMT)
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'...a short burst of Prednisone (40 mg/three times daily for 3 days, then tapered over the next 4 days)....'
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Note added at 3 days 19 hrs (2021-11-02 16:04:06 GMT)
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https://jamanetwork.com/journals/jamapediatrics/fullarticle/...
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Note added at 3 days 19 hrs (2021-11-02 16:06:12 GMT)
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https://www.uptodate.com/contents/prednisone-drug-informatio...
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Note added at 3 days 19 hrs (2021-11-02 16:11:25 GMT)
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https://pubmed.ncbi.nlm.nih.gov/8388401/
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Note added at 3 days 19 hrs (2021-11-02 16:15:57 GMT)
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'...a short burst of Prednisone (40 mg/three times daily for 3 days, then tapered over the next 4 days)....'
Example sentence:
'A Web-based survey about typical patterns of OCS administration and total steroid burst dose was administered to pulmonologists...'
Reference:
http://pubmed.ncbi.nlm.nih.gov/22183118/
http://medical-dictionary.thefreedictionary.com/burst+therapy
Discussion
Side effects of prednisone and other corticosteroids range from mild annoyances to serious, irreversible organ damage, and they occur more frequently with higher doses and more prolonged treatment.
https://www.medicinenet.com/prednisone/article.htm#what_is_p...
Common side effects include:
Retention of sodium (salt) and fluid
Weight gain
High blood pressure
Loss of potassium
Headache
Muscle weakness
Nausea
Vomiting
Acne
Thinning skin
Restlessness
Problems sleeping
Serious side effects include:
Hiccups
Puffiness of the face (moon face)
Growth of facial hair
Thinning and easy bruising of the skin
Impaired wound healing
Glaucoma
Cataracts
Ulcers in the stomach
For example, a lifetime use of prednisone makes skin so thin that it brakes at the slightest touch. A "loading" dose of it is usually smaller, then adjusted. (This from knowing an asthmatic). It is not an antibiotic or a behavioural science drug.