May 9, 2004 17:19
20 yrs ago
1 viewer *
Russian term
становится активным "сам по себе"
Russian to English
Science
Biology (-tech,-chem,micro-)
при мутациях или делециях в трансмембранном сегменте в ... рецептора становится активным "сам по себе", не требуя лигандов для активации
Proposed translations
(English)
| 5 +1 | becomes constitutively active |
nuclear
|
| 4 +3 | self-activates |
Irene N
|
| 4 +1 | activate themselves |
GaryG
|
| 3 | in itself; on its own accord |
Kirill Semenov
|
| 3 | autoactivates |
Giacomo Camaiora (X)
|
| 3 | active per se |
Elena Ivaniushina
|
Proposed translations
+1
18 hrs
Russian term (edited):
��������� ������� "��� �� ����"
Selected
becomes constitutively active
Похоже, речь идет не о "самоактивации" (хотя такое тоже встречается - см. автофосфорилирование), а о том, что "изуродованный" рецептор активен постоянно, сам по себе, не требуя никакой активации, i.e. "constitutively".
4 KudoZ points awarded for this answer.
Comment: "Именно так. Спасибо"
+1
4 mins
activate themselves
I'm not sure if "self-activate" is a medical or biological term
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Note added at 2004-05-09 17:25:32 (GMT)
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It seems that \"self-activate\" IS an (?the?) accepted term: www.biochem.arizona.edu/gillies/bc801/lecture10.pdf
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Note added at 2004-05-09 17:25:32 (GMT)
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It seems that \"self-activate\" IS an (?the?) accepted term: www.biochem.arizona.edu/gillies/bc801/lecture10.pdf
Peer comment(s):
| agree |
Natalie
: ...presenilins may, in fact, be -secretases—self-activated enzymes that... http://pubs.acs.org/hotartcl/cenear/991206/7749health.html
1 hr
|
5 mins
Kirill Semenov
Ukraine
Ukraine
Native in Russian
Ukraine
60+ books translated and published
Native in: Russian 
Works in: English to Russian, Russian
Russian term (edited):
��������� �������
in itself; on its own accord
on its own accord
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Note added at 8 mins (2004-05-09 17:27:11 GMT)
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becomes active om its own accord (what a shame ;))
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Note added at 8 mins (2004-05-09 17:27:11 GMT)
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becomes active om its own accord (what a shame ;))
+3
13 mins
Russian term (edited):
��������� �������
self-activates
The enzyme self-activates at acidic pH by removing the prosegment, leaving the mature enzyme in the proper conformation.
Peer comment(s):
| agree |
Natalie
53 mins
|
|
Спасибо!
|
|
| agree |
mk_lab
59 mins
|
|
Спасибо!
|
|
| agree |
David Mitchell
6 hrs
|
| neutral |
nuclear
: I suspect it is not "self-activation" in this case - self activation may require ligands or regulatory molecules. Sometimes genetically modified enzymes and receptors become "constitutively active" and this appars to be the case here
18 hrs
|
23 mins
Russian term (edited):
��������� �������
autoactivates
Джакомо
5 hrs
Elena Ivaniushina
Russian Federation
Russian Federation
Native in Russian
Specializes in field
Russian Federation
En-Ru: Biology, Medicine, Localization
Native in: Russian
Works in: English to Russian, Russian
Russian term (edited):
��������� ������� "��� �� ����"
active per se
Думаю, что авторы мысленно имели в виду это выражение.
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