Jul 8, 2013 18:04
10 yrs ago
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English term
Also an Engineer
Native in: Spanish (Variant: Venezuelan)
Works in: English to Spanish, Spanish to English, Spanish
was mediated primarily through impact on BMD
English to Spanish
Medical
Medical (general)
En una guía sobre la osteoporosis:
"The WHO determined that for many causes of secondary osteoporosis, fracture risk was mediated primarily through impact on BMD. [ref] For this reason, when femoral neck BMD is inserted into FRAX®, the secondary osteoporosis button is automatically inactivated."
No entiendo la idea. Hubiera pensado que es impacto "de" la densidad mineral ósea no "sobre" la densidad mineral ósea.
BMD = bone mineral density = densidad mineral ósea = DMO
Mil gracias por ayudarme a aclarar la frase
"The WHO determined that for many causes of secondary osteoporosis, fracture risk was mediated primarily through impact on BMD. [ref] For this reason, when femoral neck BMD is inserted into FRAX®, the secondary osteoporosis button is automatically inactivated."
No entiendo la idea. Hubiera pensado que es impacto "de" la densidad mineral ósea no "sobre" la densidad mineral ósea.
BMD = bone mineral density = densidad mineral ósea = DMO
Mil gracias por ayudarme a aclarar la frase
Proposed translations
(Spanish)
| 3 | deriva principalmente del efecto sobre la densidad mineral ósea |
M. C. Filgueira
|
| 3 | median el riesgo de fractura debido a la DMO |
Laura Mathier
|
References
| Tres referencias |
M. C. Filgueira
|
Proposed translations
4 days
M. C. Filgueira
Native in Spanish
Specializes in field
Química biológica
Native in: Spanish 
Works in: English to Spanish, French to Spanish, Spanish
Related KudoZ points
:
896
Selected
deriva principalmente del efecto sobre la densidad mineral ósea
Como te comenté en "Discusión", si entendí bien las referencias que te adjunté, lo que quieren decir en la frase en cuestión es que, en los cálculos realizados por el algoritmo del programa FRAX, el riesgo de fractura relacionado con muchas de las causas de osteoporosis secundaria deriva principalmente del efecto de dichas causas sobre la densidad mineral ósea.
Indico solamente un grado de confianza de 3 porque leí todo muy en diagonal. Es preciso que lo verifiques.
Saludos cordiales.
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Note added at 6 días (2013-07-15 10:57:47 GMT) Post-grading
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De nada, como siempre. ;-)
Indico solamente un grado de confianza de 3 porque leí todo muy en diagonal. Es preciso que lo verifiques.
Saludos cordiales.
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Note added at 6 días (2013-07-15 10:57:47 GMT) Post-grading
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De nada, como siempre. ;-)
4 KudoZ points awarded for this answer.
Comment: "Gracias, como siempre."
1 hr
Laura Mathier
Native in Spanish
Specializes in field
EN>SP Translator|Proofreader|QAer
Native in: Spanish (Variant: Argentine)
Works in: English to Spanish
Related KudoZ points
:
4
median el riesgo de fractura debido a la DMO
A esa frase la encontré en este texto:
http://www.iofbonehealth.org/sites/default/files/PDFs/WOD Re...
Quizás te sirva leer algunas secciones para comprender mejor el tema.
Yo busqué "secundaria" en el texto y llegué a esto.
¡Muchas suerte!
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Note added at 1 hr (2013-07-08 19:48:38 GMT)
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Algo más de información:
http://www.endocrinologia.org.mx/smne/medicos/articulo_seman...
http://www.iofbonehealth.org/sites/default/files/PDFs/WOD Re...
Quizás te sirva leer algunas secciones para comprender mejor el tema.
Yo busqué "secundaria" en el texto y llegué a esto.
¡Muchas suerte!
--------------------------------------------------
Note added at 1 hr (2013-07-08 19:48:38 GMT)
--------------------------------------------------
Algo más de información:
http://www.endocrinologia.org.mx/smne/medicos/articulo_seman...
Example sentence:
. . . se cree que las otras causas secundarias de osteoporosis median el riesgo de fractura debido a la baja DMO. Es así que cuando la DMO es ingresada en las ecuaciones de FRAX® no hay ningún peso que concuerde con estas otras causas secundarias.
Reference comments
18 hrs
M. C. Filgueira
Native in Spanish
Specializes in field
Química biológica
Native in: Spanish
Works in: English to Spanish, French to Spanish, Spanish
Related KudoZ points
:
896
Reference:
Tres referencias
Tal vez esto te aclare el panorama:
"Secondary osteoporosis. This variable is included in the FRAX calculator specifically for patients in whom hip BMD is NOT available. Enter "yes" if the patient has a disorder strongly associated with bone loss and fracture. These include type I (insulin dependent) diabetes, osteogenesis imperfecta in adults, untreated long-standing hyperthyroidism, hypogonadism or premature menopause 14. Since the impact of many secondary causes of osteoporosis on fracture risk is mediated primarily through effects on BMD, the secondary osteoporosis button is automatically inactivated when T-scores are inserted into FRAX.¹¹"
(En: http://www.google.com/url?sa=t&rct=j&q="FRAX®"+"secondary+os...
"If secondary osteoporosis is entered as a risk factor in FRAX, the algorithm assumes that the effect is mediated solely through effects on BMD. Input of BMD into the questionnaire in such patients will therefore generate the same fracture risk whether or not secondary osteoporosis is entered. However, it is likely that at least some causes of secondary osteoporosis (for example, inflammatory bowel disease) affect fracture risk by mechanisms that are partially independent of BMD and fracture risk may therefore be underestimated in such patients. There is therefore a need to investigate the accuracy of FRAX in predicting fracture risk in patients with causes of secondary osteoporosis other than rheumatoid arthritis and to establish whether their effect on fracture risk is mediated solely through effects on BMD."
(En: http://publications.nice.org.uk/osteoporosis-assessing-the-r...
"The GDG considered that risk scores are likely to underestimate risk attributed to causes of secondary osteoporosis. The GDG understands FRAX assumes that all the effect of causes of secondary osteoporosis (other than those which are covered by other questions, for example oral glucocorticoids and rheumatoid arthritis) is mediated through BMD and that by ticking this box an undefined BMD correction is used in the assessment. The GDG considered it likely that at least some causes of secondary osteoporosis affect fracture risk by mechanisms that are partially independent of BMD and fracture risk may therefore be underestimated in such patients."
(En: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0050796/)
"Secondary osteoporosis. This variable is included in the FRAX calculator specifically for patients in whom hip BMD is NOT available. Enter "yes" if the patient has a disorder strongly associated with bone loss and fracture. These include type I (insulin dependent) diabetes, osteogenesis imperfecta in adults, untreated long-standing hyperthyroidism, hypogonadism or premature menopause 14. Since the impact of many secondary causes of osteoporosis on fracture risk is mediated primarily through effects on BMD, the secondary osteoporosis button is automatically inactivated when T-scores are inserted into FRAX.¹¹"
(En: http://www.google.com/url?sa=t&rct=j&q="FRAX®"+"secondary+os...
"If secondary osteoporosis is entered as a risk factor in FRAX, the algorithm assumes that the effect is mediated solely through effects on BMD. Input of BMD into the questionnaire in such patients will therefore generate the same fracture risk whether or not secondary osteoporosis is entered. However, it is likely that at least some causes of secondary osteoporosis (for example, inflammatory bowel disease) affect fracture risk by mechanisms that are partially independent of BMD and fracture risk may therefore be underestimated in such patients. There is therefore a need to investigate the accuracy of FRAX in predicting fracture risk in patients with causes of secondary osteoporosis other than rheumatoid arthritis and to establish whether their effect on fracture risk is mediated solely through effects on BMD."
(En: http://publications.nice.org.uk/osteoporosis-assessing-the-r...
"The GDG considered that risk scores are likely to underestimate risk attributed to causes of secondary osteoporosis. The GDG understands FRAX assumes that all the effect of causes of secondary osteoporosis (other than those which are covered by other questions, for example oral glucocorticoids and rheumatoid arthritis) is mediated through BMD and that by ticking this box an undefined BMD correction is used in the assessment. The GDG considered it likely that at least some causes of secondary osteoporosis affect fracture risk by mechanisms that are partially independent of BMD and fracture risk may therefore be underestimated in such patients."
(En: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0050796/)
Discussion
Si entendí bien (verificalo), lo que quieren decir en la frase que copiaste es que, en los cálculos realizados por el algoritmo del programa FRAX, el riesgo de fractura relacionado con muchas de las causas de osteoporosis secundaria deriva principalmente del efecto de dichas causas sobre la densidad mineral ósea.
Saludos cordiales.