anchor loaded resin
Serbian translation: smola za vezivanje/pričvršćivanje
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| 12:29 Aug 6, 2022 |
| English to Serbian translations [PRO] Medical - Medical: Pharmaceuticals / oligomer conjugates | |||||||
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|  Selected response from: Natasa Stankovic Serbia Local time: 07:42 | ||||||
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| Summary of answers provided | ||||
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| 4 +1 | smola tretirana kotvom |
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| 2 | smola za vezivanje/pričvršćivanje |
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Answers
2 days 9 hrs confidence: 
peer agreement (net): +1
peer agreement (net): +1smola tretirana kotvom Explanation: "1-methyl-2-pyrrolidinone (NMP; 20 mL/g resin) is added to aminomethylpolystyrene resin (100-200 mesh; ˜1.0 mmol/g load based on nitrogen substitution; 75 g, 1 eq, Polymer Labs, UK, part #1464-X799) in a silanized, jacketed peptide vessel and the resin is allowed to swell with mixing for 1-2 hr. Following evacuation of the swell solvent, the resin is washed with dichloromethane (2×1-2 min), 5% diisopropylethylamine in 25% isopropanol/dichloromethane (2×3-4 min) and dichloromethane (2×1-2 min). After evacuation of the final wash, the resin is treated with a solution of disulfide anchor 34 in 1-methyl-2-pyrrolidinone (0.17 M; 15 mL/g resin, ˜2.5 eq) and the resin/reagent mixture is heated at 45° C. for 60 hr." https://patents.justia.com/patent/20220017901 "Zreli protein sadrži 208 aminokiselina i po strukturi je glikoprotein. Za C kraj se, posle otklanjanja aminokiselina, vezuje GPI - kotva kojom se ovaj protein zakačinje (usidri) za spoljašnji deo ćelijske membrane." https://www.bionet-skola.com/w/Prionski_protein "The GPI-anchor is covalently attached to the C-terminus of a protein and mediates the protein’s attachment to the outer leaflet of the lipid bilayer." https://www.frontiersin.org/articles/10.3389/fcell.2021.7205... https://www.bionet-skola.com/w/Prionski_protein https://www.frontiersin.org/articles/10.3389/fcell.2021.720536/full |
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8 hrs confidence:
smola za vezivanje/pričvršćivanje Explanation: R. Nedić, Rečnik polimera: anchorage - ...2. vezivanje n (jednog materijala na drugi) 3. veza f (npr. molekula niti) 4. čvrsto pričvršćenje n. -------------------------------------------------- Note added at 8 hrs (2022-08-06 21:06:57 GMT) -------------------------------------------------- ili, možda: osnovna (naneta) smola R. Nedić, Rečnik polimera: anchor coating - osnovni premaz m -------------------------------------------------- Note added at 5 days (2022-08-11 19:48:37 GMT) Post-grading -------------------------------------------------- Možda bi prevod za: EN: exon skipping oligomer conjugates for muscular distrophy mogao biti npr: SR: konjugovani(/spregnuti/složeni) oligomeri za preskakanje egzona kod mišićne distrofije Nažalost, nisam baš sigurna – ovo je samo moje nagađanje, pošto u ovoj oblasti i nisam baš puno prevodila. Nadam se da će vam bar malo pomoći ili bar dati neku ideju kako doći do korektnog prevoda. Možda vam može pomoći i nešto iz ovog stručnog teksta: Dišenova mišićna distrofija – trajući terapijski izazov. O registrovanim kauzalnim terapijama. ... Eteplirsen je prvi lek u terapiji DMD iz grupe novih terapija takozvanog preskakanja egzona (eng. exon skipping) koji je registrovala američka Uprava za hranu i lekove (Food and Drug Administration – FDA). Ovaj vid terapije nije pogodan za sve pacijente obolele od DMD, već je rezervisan za one koji imaju specifičan tip mutacije koja remeti okvir čitanja, u konkretnom slučaju pogodne za preskakanje egzona 51 u DMD genu, što čini oko 14% svih pacijenata. [15] Efekat preskakanja egzona se postiže primenom sintetičkih analoga nukleinske kiseline zvanih „antisens” – besmislenih oligonukleotida (antisense oligonucleotide – AON). Uloga AON jeste vezivanje za komplementarnu sekvencu pre-iRNK, u ovom slučaju egzon 51, vršeći uticaj na iskrajanje egzona na način da se određeni, u ovom slučaju egzon 51 ne nađe u finalnom transkriptu, što koriguje translacioni okvir čitanja i omogućava sintezu skraćenog, ali funkcionalnog proteina distrofina (Slika 3).“ http://www.drustvoneurologasrbije.org/sinapsa/SINAPSA_27_28.... |
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Reference comments
8 hrs |
| Reference Reference information: Chemical anchoring is a technique for fastening to concrete and similar substrates that provides more flexibility than mechanical anchoring. - https://www.allfasteners.com.au/news-articles/what-is-a-chem... What is resin loading? Resin loading or substitution is the number of reactive sites per gram of resin and it is typically expressed in units of mmoles per gram of resin. - https://www.peptide.com/custdocs/1198.pdf |
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