Spindle disturbances

Russian translation: повреждения веретена деления

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English term or phrase:	Spindle disturbances
Russian translation:	повреждения веретена деления
Entered by:	Igor_2006

05:08 May 30, 2019

English to Russian translations [PRO]
Medical - Medical: Pharmaceuticals / Toxicology written summar

English term or phrase: Spindle disturbances

Spindle disturbances in V79 cells with and without expression of human CYP1A2
Spindle disturbing effects in terms of c-mitosis and cytotoxicity of paracetamol were investigated in two Chinese hamster V79 cell lines, one of which (V79MZh1A2) was transfected with human cytochrome (CY) P1A2.
The present study demonstrated that paracetamol may disturb the spindle of dividing cells conveying a risk of aneuploidy.
The spindle disturbing effect was only slightly enhanced by expression of CYP1A2, suggesting that metabolic activation plays only a minor role in this genotoxic effect.
Relationship between the concentration of paracetamol in 2 hour exposure and genotoxic effects in terms of spindle disturbances measured by c-mitosis frequency in a native V79 cell line (▲) and a V79 cell line expressing human CYP1A2 (O)

Julia Berezina KudoZ activity Questions: 180 (1 open) (1 without valid answers) (6 closed without grading) Answers: 0
Local time: 10:24

повреждения веретена деления

Explanation:
Характер подобных аномалий определяется степенью повреждения веретена деления, которое может быть полным или частичным.
https://tinyurl.com/yyc5dxgq

Данная аномалия образуется в процессе незавершённого митоза в результате повреждения веретена деления; при этом нарушена не только цитотомия (разделение тела материнской клетки на две дочерние), но и кариотомия (деление ядра).
https://goarctic.ru/work/biomonitoring-cheloveka-v-yanao/

Микроядра в клетках появляются или вследствие повреждения ДНК, что свидетельствует о хромосомных, а возможно и генных мутациях при нарушении считывания нуклеотидов, или они могут быть результатом повреждения веретена деления и образованы одной или более целыми хромосомами, отставшими в анафазе митоза и не вошедшими в основное ядро
https://cyberleninka.ru/article/n/tsitogeneticheskiy-status-...

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Igor_2006
Russian Federation
Local time: 10:24

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повреждения веретена деления

Igor_2006

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spindle disturbances

повреждения веретена деления

Igor_2006
Russian Federation
Local time: 10:24
Specializes in field
Native speaker of: Russian
PRO pts in category: 1191

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Spindle disturbances

Russian translation: повреждения веретена деления

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