human CTLA4 KI, human CD3 EDG-replaced mice

Russian translation: см.

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English term or phrase:	human CTLA4 KI, human CD3 EDG-replaced mice
Russian translation:	см.
Entered by:	Nitrogen

07:13 Jun 19, 2022

English to Russian translations [PRO]
Science - Biology (-tech,-chem,micro-) / иммунология�

English term or phrase: human CTLA4 KI, human CD3 EDG-replaced mice

Efficacy of each of the anti-CTLA4 switch antibody and anti-CTLA4 non-switch antibody in a syngeneic tumor cell-transplanted model using human CTLA4 knock-in, human CD3 transgenic mouse, increase/decrease of Treg cells in tumor, and change in systemic response marker in the spleen

A ***human CTLA4 KI, human CD3 EDG-replaced mice*** (hCTLA4 KI hCD3 EDG-replaced mice), which is a hybrid of a human CTLA4 knock-in mouse and an in-house generated human CD3 EDG-replaced mouse was used.

Nitrogen KudoZ activity Questions: 1034 (none open) (38 closed without grading) Answers: 6
Local time: 23:36

см.

Explanation:
мыши/линия мышей с нокином человеческого гена CTLA4 KI и гуманизированным CD3 EDG

см.
https://www.proz.com/kudoz/english-to-russian/medical-genera...

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Note added at 1 day 4 hrs (2022-06-20 11:23:44 GMT) Post-grading
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простите, недосмотрел, когда копировал - лишнее KI:
мыши с нокином человеческого гена CTLA4 и гуманизированным CD3 EDG

Selected response from:

Igor Andreev
Local time: 23:36

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4 KudoZ points were awarded for this answer

Summary of answers provided

см.

Igor Andreev

Summary of reference entries provided

José Patrício

Answers

1 hr confidence:

human ctla4 ki, human cd3 edg-replaced mice

см.

Igor Andreev
Local time: 23:36
Specializes in field
Native speaker of:

Russian
PRO pts in category: 1427

Grading comment

Thanks

Reference comments

36 mins

Reference

Reference information:
I think you understand what replaced mice means. Anyway a remind:
In this study we have successfully established a novel mouse strain in which the entire CD3 components, i.e. CD3E, CD3D, and CD3G (referred to as CD3 EDG in this paper) were genetically humanized. - Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3–mediated therapeutics - PMC (nih.gov)

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Note added at 42 minutos (2022-06-19 07:56:40 GMT)
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Humanized Mouse Models - https://www.creative-biolabs.com/drug-discovery/therapeutics...

José Patrício
Portugal
Native speaker of:

Portuguese

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human CTLA4 KI, human CD3 EDG-replaced mice

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